Molecular mechanisms of Trypanosoma cruzi infection by oral route
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of Trypanosoma cruzi infection by oral route.
Frequent reports on outbreaks of acute Chagas' disease by ingestion of food contaminated with parasites from triatomine insects illustrate the importance of this mode of transmission. Studies on oral Trypanosoma cruzi infection in mice have indicated that metacyclic trypomastigotes invade the gastric mucosal epithelium. A key molecule in this process is gp82, a stage-specific surface glycoprote...
متن کاملMolecular analysis of early host cell infection by Trypanosoma cruzi.
Trypanosoma cruzi, the causative agent of Chagas heart disease, infects heart and other cells leading to cardiac arrest frequently followed by death. The disease affects millions of individuals in the Americas and is posing health problems because of blood transmission in the US due to large Latin American immigration. Since the current drugs present serious side effects and do not cure the chr...
متن کاملUnraveling Chagas disease transmission through the oral route: Gateways to Trypanosoma cruzi infection and target tissues
Oral transmission of Trypanosoma cruzi, the causative agent of Chagas disease, is the most important route of infection in Brazilian Amazon and Venezuela. Other South American countries have also reported outbreaks associated with food consumption. A recent study showed the importance of parasite contact with oral cavity to induce a highly severe acute disease in mice. However, it remains uncer...
متن کاملTrypanosoma cruzi Infection through the Oral Route Promotes a Severe Infection in Mice: New Disease Form from an Old Infection?
Oral transmission of Chagas disease has been documented in Latin American countries. Nevertheless, significant studies on the pathophysiology of this form of infection are largely lacking. The few studies investigating oral route infection disregard that inoculation in the oral cavity (Oral infection, OI) or by gavage (Gastrointestinal infection, GI) represent different infection routes, yet bo...
متن کاملDifferential Infectivity by the Oral Route of Trypanosoma cruzi Lineages Derived from Y Strain
BACKGROUND Diversity of T. cruzi strains is a central problem in Chagas disease research because of its correlation with the wide range of clinical manifestations and the biogeographical parasite distribution. The role played by parasite microdiversity in Chagas disease epidemiology is still debatable. Also awaits clarification whether such diversity is associated with the outcome of oral T. cr...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 2009
ISSN: 0074-0276
DOI: 10.1590/s0074-02762009000900015